6  A Phase 1/2, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral TP-3654 in Patients With Intermediate or High-Risk Primary or Secondary Myelofibrosis

6.1 Nuvisertib Monotherapy Arm 1

6.2 Nuvisertib Add-on to Ruxolitinib Arm 2

6.3 Nuvisertib and Momelotinib Combination Arm 3